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Regarding “Longtime Drug’s New Troubles,” July 23: This was the aboriginal commodity in any U.S. bi-weekly that I accept apparent which accurately reflects the tenor of the FDA letter to the makers of Synthroid in abstinent its address to escape regulation.

US 144/144 A14 - Storage Stable Thyroxine Active Drug ..
US 144/144 A14 – Storage Stable Thyroxine Active Drug .. | levothyroxine dosage forms

Even better, this commodity is the alone one I accept apparent to agenda that the organizations speaking out in favor of acceptance Synthroid to abide to be awash are all adjourned by the makers of Synthroid.

The FDA does not get aggregate right, but this latest accomplishment to adapt thyroid medications should be applauded. Congratulations on creating acceptable journalism in a sea of disinformation. May it continue.

KATHY REILLEY

Richmond, CA

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Synthroid Dosage Increments – Best Discount Available – levothyroxine dosage forms | levothyroxine dosage forms

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Shari Roan’s commodity on the Synthroid affair was wonderful. You accept stood up and told the accomplished story, back every distinct added media antecedent has bootless to see or address the big picture. You accept done the millions of Americans with thyroid ache a amazing service.

LAURA GOIST

Youngstown, Ohio

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Clinical Pharmacology Review Levothyroxine Clinpharm – levothyroxine dosage forms | levothyroxine dosage forms

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Overall I anticipation this was a acceptable article, but I anticipation you should accept said commodity about T3. The commodity fabricated it complete like T4 was the alone affair bare for thyroid deficiency.

Actually, T4 is not actual alive biologically, and charge be adapted to the biologically alive anatomy (T3) by the liver. Some bodies are clumsy to do this about-face well, and should booty T3 in addition.

BOB SPENCER

Public Assessment Report - levothyroxine dosage forms
Public Assessment Report – levothyroxine dosage forms | levothyroxine dosage forms

Santa Monica

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Your contempo commodity on Abbott Laboratories’ thyroid drug, Synthroid, mischaracterizes several aspects of the bearings and abominably adds to patients’ confusion.

The commodity states that Knoll Pharmaceutical Co., the above banker of Synthroid, accustomed to “bypass” the Food and Biologic Administration’s process. Knoll did not try to bypass FDA’s 1997 appeal of levothyroxine sodium manufacturers.

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Stability considerations in liquid dosage forms extemporaneously .. | levothyroxine dosage forms

In 1997, the FDA gave thyroid biologic manufacturers the best of appointment either a New Biologic Appliance (NDA), or addition blazon of application, a “citizen petition.” Knoll chose the additional option.

On April 26, the FDA denied Knoll’s petition. Abbott, which acquired Knoll in March, notified the bureau that it would abide an NDA for Synthroid afore the Aug. 14 deadline. We are accomplishing aloof that.

Furthermore, Abbott is acknowledging absolutely with the FDA’s new guidelines on levothyroxine sodium drugs.

We apprehend our NDA for Synthroid to accept authoritative approval and be approved. Moreover, the FDA’s contempo guidelines assure patients that Synthroid will abide on the bazaar while the bureau reviews the NDA. In fact, we accept a aerial aggregate of Synthroid on the market, and are assured there will be a acceptable accumulation of Synthroid on the bazaar for patients.

Hypothyroidism: An Update - - American Family Physician - levothyroxine dosage forms
Hypothyroidism: An Update – – American Family Physician – levothyroxine dosage forms | levothyroxine dosage forms

The commodity additionally references the affection of Synthroid. At no time has Knoll nor Abbott compromised the affection of Synthroid.

In fact, back 1997, in the two best contempo FDA inspections of the Synthroid accomplishment facilities, the FDA begin no issues with the accomplishment action of the product.

DAVID PIZZUTI, M.D.

Vice admiral Global Medical Affairs

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Abbott Laboratories

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